4-Toluenesulfonyl chloride → HCID 9912385, compound

HRID 367405Notes

Reaction equation

HRID 367405 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:24][C:25]1[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=1>>[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[N:13]([S:31]([C:28]2[CH:29]=[CH:30][C:25]([CH3:24])=[CH:26][CH:27]=2)(=[O:33])=[O:32])[CH:12]=[C:11]3[CH:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 23288077HCID 23288077, compound

Product 1

HCID 9912385HCID 9912385, compound

Procedure

from 5-cyclohexyloxy-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5a, 15.7 mg, 0.05 mmol) and 4-methylphenylsulfonyl chloride (50 mg, 0.26 mmol); HRMS-FAB+ for C27H34N2O3S: calculated MH+ : 467.23685; found: 467.23882.

Sources & evidence

ORD record
ord-e24c753a3b4d48f6a87304b9a67b047f
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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