4-Fluorobenzenesulfonyl chloride → HCID 23288128, compound

HRID 367406Notes

Reaction equation

HRID 367406 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH:6]=[C:5]2[CH:21]1[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1.ClC1C=C2C(=CC=1)NC=C2C1CCN(C)CC1.FC1C=CC(S(Cl)(=O)=O)=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:12])=[O:13])[CH:6]=[C:5]2[CH:21]1[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 114139925-Chloro-3-(1-methyl-4-piperidinyl)indoleHCID 23288115HCID 23288115, compound

Product 1

HCID 23288128HCID 23288128, compound

Procedure

(ttt) 5-Chloro-1-(4-fluorophenylsulfonyl )-3-(1-methyl-4-piperidinyl)indole (18.4 mg, 45%) from 5-chloro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5e, 25 mg, 0.1 mmol) and 4-fluorophenylsulfonyl chloride (29.2 mg, 0.15 mmol), HRMS-FAB+ for C20H20N2O2SClF, calculated MH+ : 407.09964; found: 407.09685.

Sources & evidence

ORD record
ord-8dcd82a8c806422083faf300798b8b42
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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