4-Fluorobenzenesulfonyl chloride → HCID 23288138, compound

HRID 367409Notes

Reaction equation

HRID 367409 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([Cl:20])[CH:18]=3)[C:13]([CH:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.ClC1C=C2C(C(C3CCN(C)CC3)=CN2)=CC=1.FC1C=CC(S(Cl)(=O)=O)=CC=1>>[Cl:20][C:17]1[CH:18]=[C:19]2[C:14]([C:13]([CH:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:12][N:11]2[S:8]([C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)(=[O:10])=[O:9])=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 187973681H-Indole, 6-chloro-3-(1-methyl-4-piperidinyl)-HCID 23288102HCID 23288102, compound

Product 1

HCID 23288138HCID 23288138, compound

Procedure

1-(4-Fluorophenylsulfonyl)-6-chloro-3-(1-methyl-4-piperidinyl)indole: (26.8 mg, 65%), from 6-chloro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5b, 25 mg, 0.10 mmol) and 4-fluorophenylsulfonyl chloride (29.2 mg, 0.15 mmol), HRMS-FAB+ for C20H20N2O2SClF, calculated MH+ : 407.09964; found: 407.09929.

Sources & evidence

ORD record
ord-1636e22e03a84594b4c2f8a961763e76
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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