HCID 178450981, compound → HCID 178450988, compound

HRID 36805Notes

Reaction equation

HRID 36805 reaction equation
[CH2:1]([O:5][CH:6]([O:34][CH2:35][CH2:36][CH2:37][CH3:38])[C@H:7]([CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:33])[NH2:32])[NH:8][C:9](=[O:26])[C@H:10]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH:11]C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][CH3:4]>CO.[Pd]>[CH2:1]([O:5][CH:6]([O:34][CH2:35][CH2:36][CH2:37][CH3:38])[C@H:7]([CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:32])[NH2:33])[NH:8][C:9](=[O:26])[C@H:10]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH2:11])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 178450981HCID 178450981, compound

Product 1

HCID 178450988HCID 178450988, compoundYield 98.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 100 ml of methanol was dissolved 3.73 g of N-benzyloxycarbonyl-L-leucyl-L-argininal dibutyl acetal obtained. In nitrogen atmosphere, 1 g of palladium black was added to the solution and the mixture was subjected to catalytic hydrogenation at room temperature for 2 hours. After palladium black was removed by filtration, the filtrate was concentrated under reduced pressure to give 2.75 g of L-leucyl-L-argininal dibutyl acetal.

Workup

  1. customobtained
  2. customAfter palladium black was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-18dbffb3ffe24dd28162ca1f1a413a29
Source dataset
uspto-grants-1995_05
Patent number
US05416238

Reaction notes

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