HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 368289Generated: October 25, 2026
Hydrochloric Acid → 1-Cyclopropanecarbonyl-2-(5,6-dichloro-3-pyridinecarbonyl)-hydrazine
https://huagongshe.com/reaction/368289
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cyclopropanecarbohydrazide | HCID 81396 | — |
| Reactant | 5,6-dichloropyridine-3-carbonyl Chloride | HCID 2782156 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-Cyclopropanecarbonyl-2-(5,6-dichloro-3-pyridinecarbonyl)-hydrazine | HCID 23288265 | 35% |
Reaction Steps
A mixture of cyclopropanecarboxylic acid hydrazide (1.6 g, 16 mmol) in 5% aqueous sodium hydroxide (50 mL) was cooled to 0° C. with stirring and a solution of 5,6-dichloronicotinoyl chloride (3.1 g, 14.8 mmol) in dimethoxyethane (10 mL) added over 20 minutes. This was stirred at room temperature overnight, acidified to pH 3-4 with 1N hydrochloric acid and filtered. The resulting tan solid was dried to give the desired product (1.4 g, 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06133294 |
|---|
| Source dataset | uspto-grants-2000_10 |
|---|
| ORD ID | ord-fc1cecb051884870bd2b9f77aa13ef55 |
|---|
| Source note | uspto-grants-2000_10 |
|---|
