反应详情

A solution of t-butyl-tris[(2-hydroxyethyl)thiomethyl]acetate (11.2 g, 0.029 mol) in 50 mL of pyridine is cooled to 0° C. and p-toluenesulfonyl chloride (18.3 g, 0.096 mol) is added in portions over 1 hr. The mixture is kept at 0° C. for 15 hrs. Then dichloromethane (200 mL) is added and the solution is washed four times with 100 mL of 10% hydrochloric acid, once with 100 mL of saturated sodium bicarbonate and once with 100 mL of water. The organic layer is dried over anhydrous sodium sulfate and evaporated to give t-butyl-tris[(2-tosylethyl)-thiomethyl]acetate.

1. washthe solution is washed four times with 100 mL of 10% hydrochloric acid
2. dry with materialThe organic layer is dried over anhydrous sodium sulfate
3. customevaporated