Cyclohexyl isocyanate → HCID 15485708, compound

HRID 368375Notes

Reaction equation

HRID 368375 reaction equation
[CH:1]1([N:7]=[C:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=1[OH:20]>C1(C)C=CC=CC=1>[CH:1]1([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=2[OH:20])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 49847212-Amino-5-Nitrophenol

Product 1

HCID 15485708HCID 15485708, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of cyclohexyl isocyanate (400 mg, 3.19 mmol) in toluene, 2-amino-5-nitrophenol (492 mg, 3.19 mmol) was added. The reaction mixture was stirred at 80° C. for 24 hours, then cooled to room temperature. The product was purified by precipitation from toluene and filtering (752 mg, 93%). m.p: 1850-186.0° C.; EI-MS m/z 280 (M+H)+.

Workup

  1. temperaturecooled to room temperature
  2. customThe product was purified by precipitation from toluene
  3. filtrationfiltering (752 mg, 93%)

Sources & evidence

ORD record
ord-a1eaaff04a394b9e87ab4f84d64637fe
Source dataset
uspto-grants-2000_10
Patent number
US06133319

Reaction notes

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