反应详情

To 100 mg of ethyl 1-(5-amino-6-chloropyridine-3-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate was added 3 ml of concentrated hydrochloric acid, and the mixture was heated under reflux for 2 hours. The reaction solution was allowed to cool, and the solid precipitated was collected by filtration. The solid was washed with ethanol to obtain 86 mg of the title compound as a pale yellow powder.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. temperatureto cool
4. customthe solid precipitated
5. filtrationwas collected by filtration
6. washThe solid was washed with ethanol