反应详情

温度

50 °C

To 20 ml of acetonitrile were added 6.4 g of 2,4-dichloro-5-fluoropyrimidine and 7.0 g of t-butylamine, then the mixture was stirred at 50° C. for 20 minutes. The solution was concentrated under reduced pressure, and separated by adding 40 ml of distilled water and 70 ml of chloroform. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The precipitated pale yellow crystals were dispersed in diisopropylether and collected by filtration to obtain 4.1 g of the title compound.

1. concentrationThe solution was concentrated under reduced pressure
2. customseparated
3. additionby adding 40 ml of distilled water and 70 ml of chloroform
4. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. additionThe precipitated pale yellow crystals were dispersed in diisopropylether
7. filtrationcollected by filtration