N-[2-(t-butylamino)-5-chloro-3,6-difluoropyridin-4-yl]phthalimide → N-(2-amino-5-chloro-3,6-difluoropyridin-4-yl)phthalimide

HRID 368457Notes

Reaction equation

C([NH:5][C:6]1[C:11]([F:12])=[C:10]([N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[C:9]([Cl:24])=[C:8]([F:25])[N:7]=1)(C)(C)C>FC(F)(F)C(O)=O>[NH2:5][C:6]1[C:11]([F:12])=[C:10]([N:13]2[C:14](=[O:23])[C:15]3=[CH:22][CH:21]=[CH:20][CH:19]=[C:16]3[C:17]2=[O:18])[C:9]([Cl:24])=[C:8]([F:25])[N:7]=1

Participants

Conditions

Temperature: 70 °C

Procedure

To 80 ml of trifluoroacetic acid was added all amount of the N-[2-(t-butylamino)-5-chloro-3,6-difluoropyridine-4-yl]phthalimide, and the mixture was stirred at 70° C. for 5 and half hours. The solution was concentrated under reduced pressure. The precipitate was dispersed in chloroform, and collected by filtration to obtain 19.5 g of the title compound as a colorless powder.

Workup

concentrationThe solution was concentrated under reduced pressure
additionThe precipitate was dispersed in chloroform
filtrationcollected by filtration

Sources & evidence

ORD record: ord-ffbc7749f391443da5afef5d206a5b8c
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133284

Reaction notes

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