反应详情

To 1 ml of N-methylpyrrolidone was added 410 mg of 4-amino-2,5-difluoropyridine together with 930 mg of benzylamine, and the mixture was allowed to react in nitrogen atmosphere at 150° C. for 3 days and allowed to cool. After adding 30 ml of chloroform, the mixture was washed twice with 300 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was subjected to column chromatography (silica gel, 15 g; eluent: chloroform:methanol, 1:0 and then, 50:1) to obtain 400 mg of the title compound as a colorless solid.

1. customto react in nitrogen atmosphere at 150° C. for 3 days
2. temperatureto cool
3. washthe mixture was washed twice with 300 ml of distilled water
4. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure