Trifluoroacetic acid → 3-Fluoro-5-methylpyridine-2,6-diamine

HRID 368468Notes

Reaction equation

HRID 368468 reaction equation
FC(F)(F)C(O)=O.C([NH:12][C:13]1[C:18]([F:19])=[CH:17][C:16]([CH3:20])=[C:15]([NH:21]C(C)(C)CC(C)(C)C)[N:14]=1)(C)(C)C>>[NH2:12][C:13]1[C:18]([F:19])=[CH:17][C:16]([CH3:20])=[C:15]([NH2:21])[N:14]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 177787592-t-Butylamino-3-fluoro-5-methyl-6-(1,1,3,3-tetramethylbutylamino)pyridine

Product 1

HCID 221211783-Fluoro-5-methylpyridine-2,6-diamine

Procedure

To 800 mg of trifluoroacetic acid was added 340 mg of 2-t-butylamino-3-fluoro-5-methyl-6-(1,1,3,3-tetramethylbutylamino)pyridine, and the mixture was allowed to stand at room temperature for 30 minutes. The solution was concentrated under reduced pressure to obtain crude 2,6-diamino-3-fluoro-5-methylpyridine as a pale brown solid residue.

Workup

  1. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8be6da50ddae40a281c7244e5cc51692
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

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