HCID 18506763, compound → HCID 12042412, compound

HRID 368477Notes

Reaction equation

HRID 368477 reaction equation
C([NH:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[CH3:22])[C:15](=[O:25])[C:14]([C:26]([O:28]CC)=[O:27])=[CH:13]2)[C:9]([F:31])=[CH:8][C:7]=1[F:32])(C)(C)C>Cl>[NH2:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[CH3:22])[C:15](=[O:25])[C:14]([C:26]([OH:28])=[O:27])=[CH:13]2)[C:9]([F:31])=[CH:8][C:7]=1[F:32]

Participants

3

Reactant 1

HCID 18506763HCID 18506763, compound

Product 1

HCID 12042412HCID 12042412, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 2.5 g of ethyl 1-[6-(t-butylamino)-3,5-difluoropyridine-2-yl]-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was added 10 ml of 12N hydrochloric acid, and the mixture was heated overnight under reflux. The reaction solution was allowed to stand, and the solid precipitate was collected by filtration and washed with ethanol and then, with diethylether to obtain 1.7 g of the title compound as a pale yellow powder.

Workup

  1. temperaturethe mixture was heated overnight
  2. temperatureunder reflux
  3. filtrationthe solid precipitate was collected by filtration
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-1d6703f4c8ea405ea8319ddce4dbd499
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

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