Hydrochloric Acid → HCID 22121216, compound

HRID 368489Notes

Reaction equation

HRID 368489 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:21])=[C:16]([F:20])[C:17]=3[Cl:19])[C:12](=[O:22])[C:11]([C:23]([O:25]CC)=[O:24])=[CH:10]2)[C:6]([F:28])=[CH:5][C:4]=1[Cl:29]>C(O)(=O)C>[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:21])=[C:16]([F:20])[C:17]=3[Cl:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]2)[C:6]([F:28])=[CH:5][C:4]=1[Cl:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22121156HCID 22121156, compound

Product 1

HCID 22121216HCID 22121216, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 2 ml of the mixed solution of 4N hydrochloric acid and acetic acid (1:1) was added 430 mg of ethyl 1-(6-amino-5-chloro-3-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 6 hours with stirring and allowed to cool. The precipitate was collected by filtration, and washed with ethanol and diisopropylether successively to obtain 375 mg of the title compound as a colorless powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureto cool
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with ethanol and diisopropylether successively

Sources & evidence

ORD record
ord-82c5cd5e3be54c468552b041accbba0d
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

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