HCID 54380061, compound → HCID 22121237, compound

HRID 368509Notes

Reaction equation

HRID 368509 reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([CH3:14])=[C:8]2[C:3]=1[C:4](=[O:38])[C:5]([C:33]([O:35]CC)=[O:34])=[CH:6][N:7]2[C:15]1[C:20]([F:21])=[CH:19][C:18]([F:22])=[C:17]([NH:23]CC2C=CC(OC)=CC=2)[N:16]=1>Cl>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([CH3:14])=[C:8]2[C:3]=1[C:4](=[O:38])[C:5]([C:33]([OH:35])=[O:34])=[CH:6][N:7]2[C:15]1[C:20]([F:21])=[CH:19][C:18]([F:22])=[C:17]([NH2:23])[N:16]=1

Participants

3

Reactant 1

HCID 54380061HCID 54380061, compound

Product 1

HCID 22121237HCID 22121237, compoundYield 123.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 0.99 g of ethyl 5-amino-6,7-difluoro-1-(3,5-difluoro-6-p-methoxybenzylaminopyridine-2-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was added 10 ml of 12N hydrochloric acid, and the mixture was heated under reflux for 10 hours. The reaction solution was allowed to cool, and the solid content was collected by filtration. The solid content was washed with ethanol, and then, with diethylether to obtain 880 mg of the title compound as a yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 10 hours
  3. temperatureto cool
  4. filtrationthe solid content was collected by filtration
  5. washThe solid content was washed with ethanol

Sources & evidence

ORD record
ord-a91f2cde8fc042dca09ba694d05a41ba
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

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