反应详情

温度

100 °C

To 300 mg of pyridine were added 120 mg of 5-amino-1-(6-amino-3,5-difluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 80 mg of 3-methylaminoazetidine diacetate, and 250 mg of N-methylpyrrolidine, and the mixture was stirred at 100° C. for 10 minutes. After adding 5 ml of diethylether, the mixture was stirred and allowed to cool for 1 hour, and decanted. 2 ml of ethanol was added and the mixture was stirred. The precipitate was collected by filtration and washed with ethanol and diethylether successively to obtain 72 mg of the title compound as a yellow powder.

1. stirringthe mixture was stirred
2. temperatureto cool for 1 hour
3. customdecanted
4. addition2 ml of ethanol was added
5. stirringthe mixture was stirred
6. filtrationThe precipitate was collected by filtration
7. washwashed with ethanol and diethylether successively