Diethylamine → N,N-Diethyl-2,5-difluorobenzamide

HRID 368577Notes

Reaction equation

[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[F:6][C:7]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=1[C:9](Cl)=[O:10]>>[CH2:1]([N:3]([CH2:4][CH3:5])[C:9](=[O:10])[C:8]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:7]=1[F:6])[CH3:2]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 5880822,5-Difluorobenzoyl chloride

Product 1

HCID 5044848N,N-Diethyl-2,5-difluorobenzamideYield 94%

Procedure

Diethyl amine (15.4 g, 210 mmol) and 2,5-difluorobenzoyl chloride (17.6 g, 100 mmol) were reacted using General Method E1 to afford 20.0 g of N,N-diethyl-2,5-difluorobenzamide as a clear oil, a 94% yield.

Sources & evidence

ORD record: ord-b2b87778c9934926b534e0f411f110ec
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133252

Reaction notes

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