反应详情

In 100 ml of acetone was dissolved 4.2 g of dimethyl 4-acetyl-5-hydroxyphthalate synthesized in accordance with the process of Bulletin of the Chemical Society of Japan, Vol. 57, p. 3221 (1984). To the solution were added 1.0 ml of pyrrolidine and a small amount of Molecular Sieve (3A), followed by stirring at room temperature for 3 days. Any insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography to obtain 4.6 g (86.3%) of a yellow oily substance.

1. customsynthesized in accordance with the process of Bulletin of the Chemical Society of Japan, Vol. 57, p
2. customAny insoluble material was removed by filtration
3. customthe solvent was removed by distillation under reduced pressure
4. customThe residue was purified by silica gel column chromatography
5. customto obtain 4.6 g (86.3%) of a yellow oily substance