Sodium Azide → HCID 178491312, compound

HRID 368774Notes

Reaction equation

HRID 368774 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:20]=[C:19]([C:21]#[N:22])[CH:18]=[C:17]([O:23][CH2:24][CH2:25][OH:26])[C:16]=2[O:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N-:36]=[N+:37]=[N-:38].[Na+]>CN(C)C=O>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH:14][C:15]2[CH:20]=[C:19]([C:21]3[NH:38][N:37]=[N:36][N:22]=3)[CH:18]=[C:17]([O:23][CH2:24][CH2:25][OH:26])[C:16]=2[O:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=2)(=[O:12])=[O:13])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 23288652HCID 23288652, compound

Product 1

HCID 178491312HCID 178491312, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to Example 140, by reacting 4-tert-butyl-N-[5-cyano-3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-phenyl]-benzenesulphonamide and sodium azide in N,N-dimethylformamide there was obtained 4-tert-butyl-N-[3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-5-(1 H-tetrazol-5-yI)-phenyl]-benzenesulphonamide as a white foam.

Sources & evidence

ORD record
ord-6f22a2d4b4be4551b0a9234ef1aa3490
Source dataset
uspto-grants-2000_10
Patent number
US06133442

Reaction notes

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