HCID 23288298, compound → HCID 23288296, compound

HRID 368782Notes

Reaction equation

HRID 368782 reaction equation
[CH2:1]([C:8]([C:23]#[N:24])([CH2:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O.O1CCOCC1>[CH2:1]([CH:8]([CH2:12][C:13]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)=[O:22])[C:23]#[N:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 23288298HCID 23288298, compound

Product 1

HCID 23288296HCID 23288296, compound

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

A solution of 2-benzyl-2-cyano-4-oxo-4-(3,4-dichlorophenyl)-butanoic acid (5 g, 13.8 mmol) in 10% water/1,4-dioxane (250 ml) was refluxed for about 24 hours. The solvents were removed under reduced pressure and the residue was purified by flash chromatography, using cyclohexane/ethyl acetate 0÷15 as eluent. The title compound was obtained as a colourless solid (2.7 g, 62%) (m.p. 101°-102° C.)

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-957d8330e6ab4a6a926d088286ea16e7
Source dataset
uspto-grants-2000_10
Patent number
US06133302

Reaction notes

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