HCID 23288298, compound → HCID 23288296, compound

Participants

Reaction Steps

A solution of 2-benzyl-2-cyano-4-oxo-4-(3,4-dichlorophenyl)-butanoic acid (5 g, 13.8 mmol) in 10% water/1,4-dioxane (250 ml) was refluxed for about 24 hours. The solvents were removed under reduced pressure and the residue was purified by flash chromatography, using cyclohexane/ethyl acetate 0÷15 as eluent. The title compound was obtained as a colourless solid (2.7 g, 62%) (m.p. 101°-102° C.)

Provenance & Evidence