Acetic Acid → 4-Acetoxy-2-fluorobenzoic acid
Reaction equation
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](O)(=[O:14])[CH3:13].S(=O)(=O)(O)O>O>[C:12]([O:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1)(=[O:14])[CH3:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of anhydrous acetic acid were placed in a two-necked flask, and mixed. 5 Drops of sulfuric acid were added to the mixture under cooling with water. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Thereafter, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration. The crystal was dried in vacuum, and used in the next step.
Workup
- additionmixed
- temperatureAfter heat generation
- filtrationa precipitated crystal was recovered by filtration
- customThe crystal was dried in vacuum
Sources & evidence
- ORD record
- ord-5349577655894c66b3857dffd8eccef1
- Source dataset
- uspto-grants-2000_10
- Patent number
- US06133469
Reaction notes
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