Acetic Acid → 4-Acetoxy-2-fluorobenzoic acid

Participants

Reaction Conditions

Reaction Steps

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of anhydrous acetic acid were placed in a two-necked flask, and mixed. 5 Drops of sulfuric acid were added to the mixture under cooling with water. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Thereafter, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration. The crystal was dried in vacuum, and used in the next step.

Provenance & Evidence