反应详情

N-ethoxycarbonyl-3-amino-4,4-dimethyl-pentan-2-one (203 mg) is dissolved in 48% aqueous hydrobromic acid (4 ml) and the solution is stirred under reflux for 6 hours. The reaction mixture is then evaporated under reduced pressure to give a solid residue, that is further purified by recrystallisation (from ethanol/diethylether) to afford 149 mg of pure (3RS)-3-amino-4,4-dimethyl-pentan-2-one hydrobromide (m.p. 218°-220° C.)

1. temperatureunder reflux for 6 hours
2. customThe reaction mixture is then evaporated under reduced pressure
3. customto give a solid residue, that
4. customis further purified by recrystallisation (from ethanol/diethylether)