Hydrogen Bromide → (3RS)-3-amino-4,4-dimethyl-pentan-2-one hydrobromide

HRID 36880Notes

Reaction equation

HRID 36880 reaction equation
C(OC([NH:6][CH:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8](=[O:10])[CH3:9])=O)C.[BrH:15]>>[BrH:15].[NH2:6][CH:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8](=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19936531N-ethoxycarbonyl-3-amino-4,4-dimethyl-pentan-2-one

Product 1

HCID 19936524(3RS)-3-amino-4,4-dimethyl-pentan-2-one hydrobromide

Procedure

N-ethoxycarbonyl-3-amino-4,4-dimethyl-pentan-2-one (203 mg) is dissolved in 48% aqueous hydrobromic acid (4 ml) and the solution is stirred under reflux for 6 hours. The reaction mixture is then evaporated under reduced pressure to give a solid residue, that is further purified by recrystallisation (from ethanol/diethylether) to afford 149 mg of pure (3RS)-3-amino-4,4-dimethyl-pentan-2-one hydrobromide (m.p. 218°-220° C.)

Workup

  1. temperatureunder reflux for 6 hours
  2. customThe reaction mixture is then evaporated under reduced pressure
  3. customto give a solid residue, that
  4. customis further purified by recrystallisation (from ethanol/diethylether)

Sources & evidence

ORD record
ord-46d3bf04f9f64d0fb7cfa517cb176bc7
Source dataset
uspto-grants-1995_05
Patent number
US05418238

Reaction notes

Loading…