HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → 1-Formyl-4-(4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| Product | 1-Formyl-4-(4-methoxyphenyl)piperazine | HCID 23288771 | — |
Reaction Steps
A mixture of 1-(4-methoxyphenyl)piperazine (XI, 7.41 g) and ethyl formate (108 ml) is stirred at reflux for 3 hr. The mixture is then cooled, concentrated, and the residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98). The appropriate fractions are pooled and concentrated to give 1-formyl-4-(4-methoxyphenyl)piperazine (VI), NMR (CDCl3) δ 3.05, 3.54, 3.71, 3.78, 6.88, 8.10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133446 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-bf36939d21b241d38a0977748842d6d1 |
| Source note | uspto-grants-2000_10 |