反应详情

A mixture of 1-(4-methoxyphenyl)piperazine (XI, 7.41 g) and ethyl formate (108 ml) is stirred at reflux for 3 hr. The mixture is then cooled, concentrated, and the residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98). The appropriate fractions are pooled and concentrated to give 1-formyl-4-(4-methoxyphenyl)piperazine (VI), NMR (CDCl3) δ 3.05, 3.54, 3.71, 3.78, 6.88, 8.10.

1. temperatureat reflux for 3 hr
2. temperatureThe mixture is then cooled
3. concentrationconcentrated
4. customthe residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98)
5. concentrationconcentrated