HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 368900Generated: October 27, 2026
Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → (2S)-3-(2,4-Difluorophenyl)-3-buten-2-ol
https://huagongshe.com/reaction/368900
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | (3S)-2-(2,4-Difluorophenyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-1-butene | HCID 70105313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S)-3-(2,4-Difluorophenyl)-3-buten-2-ol | HCID 15130435 | — |
Reaction Steps
A mixture of crude 5a, (870) and pyridinium-p-toluenesulfonate (350 g, 1.39 mole) in ethanol (12 L) was heated at 60° C. for 9 hours. The reaction mixture was concentrated in vacuo and co-evaporated with toluene. The residue was diluted with toluene and the resulting solid was removed by filtration. The filtrate was evaporated under reduced pressure to give the crude 6a as light brown oil (664 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06133485 |
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| Source dataset | uspto-grants-2000_10 |
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| ORD ID | ord-488496685dd2454d8cea391c9d8d1979 |
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| Source note | uspto-grants-2000_10 |
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