反应详情

温度

60 °C

A mixture of crude 5a, (870) and pyridinium-p-toluenesulfonate (350 g, 1.39 mole) in ethanol (12 L) was heated at 60° C. for 9 hours. The reaction mixture was concentrated in vacuo and co-evaporated with toluene. The residue was diluted with toluene and the resulting solid was removed by filtration. The filtrate was evaporated under reduced pressure to give the crude 6a as light brown oil (664 g).

1. concentrationThe reaction mixture was concentrated in vacuo and co-evaporated with toluene
2. additionThe residue was diluted with toluene
3. customthe resulting solid was removed by filtration
4. customThe filtrate was evaporated under reduced pressure