反应详情

To a solution of 2-cyano-3-pyridylacetonitrile (2 g, 0.014 mol) in toluene (20 ml) is added benzylmagnesium bromide 8.4 ml, 2N in tetrahydrofuran, 0.17 mol) at ambient temperature. After 1 h the reaction is quenched with a saturated solution of ammonium chloride. The product is extracted with ethyl acetate and the organic layer washed with 2N NaOH and water. The product is purified by flash column chromatography on silica gel (10:3 toluene/acetone) affording the title compound. Mass M+H 236; mp 113-116° C.

1. customAfter 1 h the reaction is quenched with a saturated solution of ammonium chloride
2. extractionThe product is extracted with ethyl acetate
3. washthe organic layer washed with 2N NaOH and water
4. customThe product is purified by flash column chromatography on silica gel (10:3 toluene/acetone)