反应详情

温度

60 °C

Trifluoroacetic acid (50 ml), acetic acid (50 ml) and sodium perborate tetrahydrate (26.6 g) were added to methyl 4-amino-2,5-difluoro-3-methylbenzoate (7.5 g), and the mixture was stirred at 60° C. for 24 hours. Impurities in the reaction mixture was removed by filtration, chloroform was added to the resultant filtrate, and the resultant mixture was washed with water. After an organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain the title compound (6.1 g) as a reddish brown oil.

1. customImpurities in the reaction mixture was removed by filtration, chloroform
2. additionwas added to the resultant filtrate
3. washthe resultant mixture was washed with water
4. dry with materialAfter an organic layer was dried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure