反应详情

Concentrated hydrochloric acid (15 ml) and acetic acid (5 ml) were added to methyl 2,5-difluoro-3-methyl-4-nitrobenzoate (9.1 g), and the mixture was heated under reflux for 3 hours. After the reaction mixture was cooled back to room temperature, water was added to conduct extraction with diethyl ether. After an organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain the title compound (6.1 g) as a brown oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. extractionextraction with diethyl ether
4. dry with materialAfter an organic layer was dried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure