Hydrochloric Acid → HCID 17782774, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (2 ml) was added to ethyl 7-amino-1-(6-tert-butylamino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 5 hours. After the reaction mixture was cooled back to room temperature, water (2 ml) was added thereto. Solids deposited were collected by filtration and washed successively with water, ethanol and diethyl ether to obtain the title compound (72 mg) as a pale yellow powder.

Provenance & Evidence