Hydrochloric Acid → HCID 17782774, compound

HRID 369215Notes

Reaction equation

HRID 369215 reaction equation
Cl.[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:32])[C:8]([C:27]([O:29]CC)=[O:28])=[CH:9][N:10]2[C:14]2[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([NH:22]C(C)(C)C)[N:15]=2)=[CH:5][C:4]=1[F:33]>O>[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:32])[C:8]([C:27]([OH:29])=[O:28])=[CH:9][N:10]2[C:14]2[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([NH2:22])[N:15]=2)=[CH:5][C:4]=1[F:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23284713HCID 23284713, compound

Product 1

HCID 17782774HCID 17782774, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Concentrated hydrochloric acid (2 ml) was added to ethyl 7-amino-1-(6-tert-butylamino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 5 hours. After the reaction mixture was cooled back to room temperature, water (2 ml) was added thereto. Solids deposited were collected by filtration and washed successively with water, ethanol and diethyl ether to obtain the title compound (72 mg) as a pale yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 5 hours
  3. filtrationSolids deposited were collected by filtration
  4. washwashed successively with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-45b0049eee52481c854d0d201001f868
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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