Methylamine → HCID 69958167, compound

HRID 369219Notes

Reaction equation

HRID 369219 reaction equation
[NH2:1][C:2]1[C:3]([F:28])=[CH:4][C:5]([F:27])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15](F)[C:16]=3[N+:18]([O-:20])=[O:19])[C:11](=[O:23])[C:10]([C:24]([OH:26])=[O:25])=[CH:9]2)[CH:7]=1.[CH3:29][NH2:30]>N1C=CC=CC=1>[CH3:2][NH2:1].[NH2:1][C:2]1[C:3]([F:28])=[CH:4][C:5]([F:27])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([NH:30][CH3:29])[C:16]=3[N+:18]([O-:20])=[O:19])[C:11](=[O:23])[C:10]([C:24]([OH:26])=[O:25])=[CH:9]2)[CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284747HCID 23284747, compound

Product 1

HCID 69958167HCID 69958167, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(5-Amino-2,4-difluorophenyl)-6,7-difluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg) and a 40% aqueous solution (172 mg) of methylamine were added to pyridine (1 ml), and the mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure, and ethanol was added to the residue to collect solids by filtration. The solids were washed successively with ethanol and diethyl ether to obtain the title compound (122 mg) as an orange powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure, and ethanol
  2. additionwas added to the residue
  3. customto collect solids
  4. filtrationby filtration
  5. washThe solids were washed successively with ethanol and diethyl ether

Sources & evidence

ORD record
ord-e215e436bd824d398ec8df40d8929c04
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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