Pyridine → HCID 23284709, compound

Participants

Reaction Steps

8-Chloro-6,7-difluoro-1-(2,4-difluoro-3-methylaminophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (120 mg) and a 40% aqueous solution (120 mg) of methylamine were added to pyridine (500 mg), and the mixture was stirred at room temperature for 3 hours. Ethanol (1 ml) was added to the reaction mixture, and the resultant mixture was stirred for 2 hours. Deposits were collected by filtration and washed successively with ethanol and diisopropyl ether to obtain the title compound (193 mg) as a colorless powder.

Provenance & Evidence