Pyridine → HCID 23284709, compound

HRID 369225Notes

Reaction equation

HRID 369225 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([F:26])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([NH:19][CH3:20])[C:13]=1[F:21])[CH:9]=[C:8]([C:22]([OH:24])=[O:23])[C:7]2=[O:25].CN.[N:30]1C=CC=C[CH:31]=1>C(O)C>[Cl:1][C:2]1[C:3]([NH:30][CH3:31])=[C:4]([F:26])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([NH:19][CH3:20])[C:13]=1[F:21])[CH:9]=[C:8]([C:22]([OH:24])=[O:23])[C:7]2=[O:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6329MethylamineHCID 23284691HCID 23284691, compound

Product 1

HCID 23284709HCID 23284709, compoundYield 156.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8-Chloro-6,7-difluoro-1-(2,4-difluoro-3-methylaminophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (120 mg) and a 40% aqueous solution (120 mg) of methylamine were added to pyridine (500 mg), and the mixture was stirred at room temperature for 3 hours. Ethanol (1 ml) was added to the reaction mixture, and the resultant mixture was stirred for 2 hours. Deposits were collected by filtration and washed successively with ethanol and diisopropyl ether to obtain the title compound (193 mg) as a colorless powder.

Workup

  1. filtrationDeposits were collected by filtration
  2. washwashed successively with ethanol and diisopropyl ether

Sources & evidence

ORD record
ord-bea575507c9a4a5a96387ff66092c836
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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