Hydrochloric Acid → HCID 23284671, compound

Participants

Reaction Steps

Ethyl 6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg) was added to a mixed liquid (1:1, v/v; 4 ml) of 2N hydrochloric acid and acetic acid, and the mixture was stirred and heated under reflux for 5 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (358 mg) as a colorless powder.

Provenance & Evidence