Hydrochloric Acid → HCID 23284671, compound

HRID 369249Notes

Reaction equation

HRID 369249 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[F:12])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([O:21][CH3:22])[CH:15]=1)[CH:7]=[C:6]([C:23]([O:25]CC)=[O:24])[C:5]2=[O:28].Cl>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[F:12])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([O:21][CH3:22])[CH:15]=1)[CH:7]=[C:6]([C:23]([OH:25])=[O:24])[C:5]2=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23284791HCID 23284791, compound

Product 1

HCID 23284671HCID 23284671, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg) was added to a mixed liquid (1:1, v/v; 4 ml) of 2N hydrochloric acid and acetic acid, and the mixture was stirred and heated under reflux for 5 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (358 mg) as a colorless powder.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 5 hours
  3. filtrationDeposits were collected by filtration
  4. washwashed with ethanol and diisopropyl ether in that order

Sources & evidence

ORD record
ord-4bdfaaeeeacc4fc08e4b9f3633d676e5
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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