Methylamine → HCID 23284798, compound

HRID 369250Notes

Reaction equation

HRID 369250 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15](F)[C:16]=3[Cl:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[CH:7]=1.[CH3:26][NH2:27]>N1C=CC=CC=1>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15]([NH:27][CH3:26])[C:16]=3[Cl:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284688HCID 23284688, compound

Product 1

HCID 23284798HCID 23284798, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(5-Amino-2-fluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) was added to a mixed liquid of a 40% aqueous solution (103 mg) of methylamine and pyridine (1 ml), and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, and ethanol was added to the residue. Solids formed were collected by filtration and washed with hexane to obtain the title compound (85 mg) as a pale yellow powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure, and ethanol
  2. additionwas added to the residue
  3. customSolids formed
  4. filtrationwere collected by filtration
  5. washwashed with hexane

Sources & evidence

ORD record
ord-4381092e6693451da2125003e1a10e37
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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