Methylamine → HCID 23284710, compound

Participants

Reaction Steps

1-(5-Amino-2,4-difluorophenyl)-7-fluoro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) was added to a mixed liquid of a 40% aqueous solution (120 mg) of methylamine and pyridine (3 ml), and the mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure. The residue was acidified with 3% citric acid, and solids formed were collected by filtration. The solids were washed with water, ethanol and hexane to obtain the title compound (70 mg) as a yellow powder.

Provenance & Evidence