Methylamine → HCID 23284710, compound

HRID 369251Notes

Reaction equation

HRID 369251 reaction equation
[NH2:1][C:2]1[C:3]([F:27])=[CH:4][C:5]([F:26])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([N+:19]([O-:21])=[O:20])=[C:15](F)[CH:16]=3)[C:11](=[O:22])[C:10]([C:23]([OH:25])=[O:24])=[CH:9]2)[CH:7]=1.[CH3:28][NH2:29]>N1C=CC=CC=1>[NH2:1][C:2]1[C:3]([F:27])=[CH:4][C:5]([F:26])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([N+:19]([O-:21])=[O:20])=[C:15]([NH:29][CH3:28])[CH:16]=3)[C:11](=[O:22])[C:10]([C:23]([OH:25])=[O:24])=[CH:9]2)[CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284690HCID 23284690, compound

Product 1

HCID 23284710HCID 23284710, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(5-Amino-2,4-difluorophenyl)-7-fluoro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) was added to a mixed liquid of a 40% aqueous solution (120 mg) of methylamine and pyridine (3 ml), and the mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure. The residue was acidified with 3% citric acid, and solids formed were collected by filtration. The solids were washed with water, ethanol and hexane to obtain the title compound (70 mg) as a yellow powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customformed
  3. filtrationwere collected by filtration
  4. washThe solids were washed with water, ethanol and hexane

Sources & evidence

ORD record
ord-0116e092e19d45efa02e3ae3fdb764b9
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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