Citric Acid → HCID 23284787, compound

Participants

Reaction Steps

1-(5-Amino-2,4-difluorophenyl)-7,8-difluoro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70 mg) was added to a mixed liquid of a 40% aqueous solution (80 mg) of methylamine and pyridine (2 ml), and the mixture was stirred at room temperature for 1 hour. The solution was acidified with 3% citric acid (10 ml), and solids formed were collected by filtration. The solids were washed with water, ethanol and hexane to obtain the title compound (56 mg) as a yellow powder.

Provenance & Evidence