Citric Acid → HCID 23284787, compound

HRID 369254Notes

Reaction equation

HRID 369254 reaction equation
[NH2:1][C:2]1[C:3]([F:28])=[CH:4][C:5]([F:27])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([N+:20]([O-:22])=[O:21])=[C:15](F)[C:16]=3[F:18])[C:11](=[O:23])[C:10]([C:24]([OH:26])=[O:25])=[CH:9]2)[CH:7]=1.[CH3:29][NH2:30].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>N1C=CC=CC=1>[NH2:1][C:2]1[C:3]([F:28])=[CH:4][C:5]([F:27])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([N+:20]([O-:22])=[O:21])=[C:15]([NH:30][CH3:29])[C:16]=3[F:18])[C:11](=[O:23])[C:10]([C:24]([OH:26])=[O:25])=[CH:9]2)[CH:7]=1

Participants

5

Reactant 3

HCID 311Citric AcidHCID 6329MethylamineHCID 23284802HCID 23284802, compound

Product 1

HCID 23284787HCID 23284787, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(5-Amino-2,4-difluorophenyl)-7,8-difluoro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70 mg) was added to a mixed liquid of a 40% aqueous solution (80 mg) of methylamine and pyridine (2 ml), and the mixture was stirred at room temperature for 1 hour. The solution was acidified with 3% citric acid (10 ml), and solids formed were collected by filtration. The solids were washed with water, ethanol and hexane to obtain the title compound (56 mg) as a yellow powder.

Workup

  1. customformed
  2. filtrationwere collected by filtration
  3. washThe solids were washed with water, ethanol and hexane

Sources & evidence

ORD record
ord-b421a1740b514b6aae28a071c1715e4f
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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