反应详情

1-(6-Amino-5-fluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (158 mg) and an aqueous solution (about 40%; 165 mg) of methylamine were added to pyridine (480 mg), and the mixture was stirred at room temperature for 17 hours. The reaction mixture was concentrated under reduced pressure, and ethanol (1 ml) was added to the residue. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (168 mg) as a pale yellow powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure, and ethanol (1 ml)
2. additionwas added to the residue
3. filtrationDeposits were collected by filtration
4. washwashed with ethanol and diisopropyl ether in that order