Hydrochloric Acid → HCID 23284724, compound

Participants

Reaction Steps

Ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg) was added to a mixed liquid (1:1, v/v; 2.5 ml) of 2N hydrochloric acid and acetic acid, and the mixture was stirred and heated under reflux for 2 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (351 mg) as a colorless powder.

Provenance & Evidence