Hydrochloric Acid → HCID 23284724, compound

HRID 369259Notes

Reaction equation

HRID 369259 reaction equation
[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([O:19][CH3:20])[CH:13]=1)[CH:9]=[C:8]([C:21]([O:23]CC)=[O:22])[C:7]2=[O:26].Cl>C(O)(=O)C>[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([O:19][CH3:20])[CH:13]=1)[CH:9]=[C:8]([C:21]([OH:23])=[O:22])[C:7]2=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23284662HCID 23284662, compound

Product 1

HCID 23284724HCID 23284724, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg) was added to a mixed liquid (1:1, v/v; 2.5 ml) of 2N hydrochloric acid and acetic acid, and the mixture was stirred and heated under reflux for 2 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (351 mg) as a colorless powder.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. filtrationDeposits were collected by filtration
  4. washwashed with ethanol and diisopropyl ether in that order

Sources & evidence

ORD record
ord-82cb4b10e2ed47e199264910f3406263
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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