Hydrogen Bromide → HCID 23284731, compound

HRID 369261Notes

Reaction equation

HRID 369261 reaction equation
[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([O:19]C)[CH:13]=1)[CH:9]=[C:8]([C:21]([O:23]CC)=[O:22])[C:7]2=[O:26].Br>C(O)(=O)C>[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([OH:19])[CH:13]=1)[CH:9]=[C:8]([C:21]([OH:23])=[O:22])[C:7]2=[O:26]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 23284662HCID 23284662, compound

Product 1

HCID 23284731HCID 23284731, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.3 g) was added to a mixed liquid (1:1, v/v; 20 ml) of 47% hydrobromic acid and acetic acid, and the mixture was stirred and heated under reflux for 78 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (1.63 g) as a colorless powder.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 78 hours
  3. filtrationDeposits were collected by filtration
  4. washwashed with ethanol and diisopropyl ether in that order

Sources & evidence

ORD record
ord-d94e69a3b80b4f8196a7031f8d7fd444
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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