Hydrogen Bromide → HCID 23284734, compound

HRID 369263Notes

Reaction equation

HRID 369263 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[F:12])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([O:21]C)[CH:15]=1)[CH:7]=[C:6]([C:23]([O:25]CC)=[O:24])[C:5]2=[O:28].Br>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[F:12])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([OH:21])[CH:15]=1)[CH:7]=[C:6]([C:23]([OH:25])=[O:24])[C:5]2=[O:28]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 23284791HCID 23284791, compound

Product 1

HCID 23284734HCID 23284734, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.3 g) was added to a mixed liquid (1:1, v/v; :30 ml) of 47% hydrobromic acid and acetic acid, and the mixture was stirred and refluxed for 44 hours. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (1.65 g) as a colorless powder.

Workup

  1. temperaturerefluxed for 44 hours
  2. filtrationDeposits were collected by filtration
  3. washwashed with ethanol and diisopropyl ether in that order

Sources & evidence

ORD record
ord-a398881a0f0a4f08a23ab76b9a29c715
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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