反应详情

温度

50 °C

1-(5-Amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg), ethanolamine (35 mg) and triethylamine (200 mg) were added to pyridine (600 mg), and the mixture was stirred at 50° C. for 15.5 hours. The reaction mixture was concentrated under reduced pressure. A process of adding ethanol (3 ml) to the residue and then concentrating the mixture under reduced pressure was conducted twice repeatedly. Ethanol (1 ml) was added to the resultant residue, and deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (188 mg) as a pale brown powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. concentrationA process of adding ethanol (3 ml) to the residue and then concentrating the mixture under reduced pressure
3. additionEthanol (1 ml) was added to the resultant residue, and deposits
4. filtrationwere collected by filtration
5. washwashed with ethanol and diisopropyl ether in that order