HCID 23284766, compound → HCID 23284742, compound

Participants

Reaction Steps

12N Hydrochloric acid (10 ml) was added to ethyl 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg), and the mixture was stirred overnight while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration and washed successively with water and ethanol to obtain the title compound (230 mg) as a colorless powder.

Provenance & Evidence